Best Cleaners For Puppy Accidents - Updated November 2025

5,822 Reviews Scanned

Quick & Easy Cleanup: Say goodbye to messy accidents with pee and poo soaked paper towels. Simply sprinkle this on, sweep into a dustpan, and dispose - leaving zero residue or odor behind!
Hands Stay Clean with Mess Cleaner: No more accidental skin contact with pet messes, your hands stay squeaky clean throughout the cleanup process with upto 40 uses, eliminating the yucky factor of...
Essential Oil Aroma: Enjoy a refreshing blend of essential oils that deodorize pet odors as you clean up. It's safe for both dogs and cats with a fresh-smelling environment after every use.
Multipurpose Uses: This isn't just for litter boxes! Use it to deodorize all the hard surfaces where accidents may occur with zero residue or odor left behind. It's also handy for quickly cleaning up...
Safe & Non-Toxic: Formulated with non-toxic ingredients, this is safe for use around your beloved pets at home. You can have peace of mind knowing it won't harm your furry friends.

Rocco & Roxie Extreme Stain & Odor Eliminator for Strong Odor, Pet Urine Enzyme Cleaner Destroyer, Stain Remover, Dog Poop and Cat Pee, Enzymatic Carpet Cleaner Spray for Home, Puppy Potty Training

Eliminates Stains, Odors, & Residue: If it’s gross, it’s gone; from blowouts, urine, vomit, and other organic spills; Rocco & Roxie stain & odor eliminator has a subtle Meyer lemon scent that...
Every Surface, Every Time: Our fast-acting carpet stain remover spray formula works great on floors, furniture, clothing, pet bedding, litter boxes, travel crates, hamster cages, cars, campers, and...
Minerals & Enzymes: The key is getting to the problem deep-down, so we added a mineral-based odor neutralizer to our bio-enzymatic formula; upon contact with tough stains & odors, this pet enzyme...
Gentle & Safe Carpet Spray: Safe to use around pets and children, when used as directed; chlorine-free, color-safe with no hazardous propellants; Certified Safe for all carpets with the Seal of...
Buy With Confidence: You want the best for your best friend; we do, too; if you are not satisfied with the performance of this pet odor eliminator and stain remover, contact us; we are determined to...

Simple Solution Extreme Pet Stain and Odor Eliminator Spray for Dogs and Cats, Dog Urine Remover, Enzymatic Cleaner, Kitten & Puppy Essentials Pee & Poop Stain Remover for Carpets & Floors, 1 Gallon

EXTREMELY EFFECTIVE: Three times stronger than standard cleaners, this powerful enzymatic spray eliminates the toughest dog and cat messes—urine, feces, and vomit—faster and more completely,...
ERASE ODORS AND STAINS: Professional-strength Pro-Bacteria and enzyme formula penetrates deep to break down and eliminate organic pet messes at the source, removing tough stains and odors while...
STRONG & SAFE ON SURFACES: Tough on pet messes yet safe for use throughout your home, this cleaner removes dog and cat stains and odors—including urine, feces, and vomit—from carpets, rugs,...
TOUGH ON STAINS, NOT ON YOUR FAMILY: Professional-strength cleaning power that eliminates the toughest dog and cat messes while remaining safe for use around children and pets when applied as...
SIMPLE SOLUTION: it’s just that…a simple solution to all of your pets’ messes – wherever they may be; We offer easy-to-use, no-hassle products that will effectively help you keep your home...

Zorbent Pet Accident Cleanup – Odor Remover for Dog & Cat Messes. Absorbs 1 Gallon. Pet-Safe Cleaner for Urine, Vomit, Poop & Accidents on Hardwood, Tile, Vinyl, Concrete, Short Carpet & Rugs, 5 qt

FAST & EASY PET MESS CLEANUP – Just pour, mix, and sweep! Instantly absorbs urine, poop, vomit, diarrhea, hairballs, and more—no scrubbing or re-cleaning required.
POWERFUL ODOR ELIMINATOR, NOT A COVER-UP – Instantly eliminates even the strongest pet odors like urine, vomit, and diarrhea—without covering them up. Zorbent encapsulates and neutralizes strong...
SUPER ABSORBENT FORMULA – Each 5-quart jug encapsulates up to 1 gallon of liquid for quick, effective cleanup on all types of surfaces.
PET-SAFE & NON-TOXIC – Made with 100% natural, non-hazardous ingredients that are safe for pets, kids, and the environment. No harsh chemicals or perfumes.
WORKS ON ANY SURFACE – Lifts messes from tile, carpet, concrete, wood, and even rough or porous floors with ease. Great for homes, kennels, and patios.

Nellie's Pet Stain & Odour Remover - Lemongrass Scented - Safe on Fabrics & Carpets - Pet-Safe & Powerful Formula - Removes Stains & Odours for a Fresher Home - Friendly Cleaner for Pet Accidents

Effective Stain & Odour Removal - Say goodbye to stubborn stains and unpleasant odours caused by pet accidents. Nellie’s Pet Stain & Odour Remover quickly tackles messes, from puppy puddles to...
Pet-Safe & Powerful Formula - Nellie’s is tough on stains and odours yet gentle enough for your pets, providing peace of mind while ensuring your home stays clean. Free of harsh chemicals, the...
Lemongrass Scented Freshness - Experience a cleaner home with the uplifting scent of lemongrass. This pet stain and odour remover doesn’t just clean; it leaves behind a fresh aroma that enhances...
Versatile Use on Fabrics & Carpets - Safe for use on a wide range of surfaces, Nellie’s Pet Stain & Odour Remover is perfect for fabrics, carpets, and upholstery. Its versatility makes it a...
Convenient & Planet Friendly Solution - Shake, spray, and wipe—cleaning up pet accidents has never been easier. Designed with environmentally conscious pet owners in mind, this product combines...

ON SALE NOW!6

Sprinkle & Sweep Pet Accident Cleanup for all Hard Surface - Non Toxic Quick Pet Mess Cleaner & Odor Remover for Urine, Poop, Vomit, Diarrhea & Potty Training (1Bag + Sweepr Kit + 1 Spray)

All-in-One Mess Cleanup & Odor Remover Set: This comprehensive package the ultimate bundle comes with a 15oz bag of high-performance clumping mess cleaner, a sturdy sweeper kit (dust pan and brush...
Hands Stay Clean with Mess Cleaner: No more accidental skin contact with pet messes, your hands stay squeaky clean throughout the cleanup process with upto 40 uses, eliminating the yucky factor of...
Essential Oil Aroma: Enjoy a refreshing blend of essential oils that deodorize pet odors as you clean up. It's safe for both dogs and cats with a fresh-smelling environment after every use.
Multipurpose Uses: This isn't just for litter boxes! Use it to deodorize all the hard surfaces where accidents may occur with zero residue or odor left behind. It's also handy for quickly cleaning up...
Safe & Non-Toxic: Formulated with non-toxic ingredients, this is safe for use around your beloved pets at home. You can have peace of mind knowing it won't harm your furry friends.

ON SALE NOW!7

Sprinkle & Sweep Pet Accident Cleanup for all Hard Surface - Non Toxic Quick Pet Mess Cleaner & Odor Remover for Urine, Poop, Vomit, Diarrhea & Potty Training, Hair Balls (1Bag + Sweeper Kit)

Complete Cleaning Kit: Each set includes a 15oz bag of premium clumping mess & odor cleanup for optimal odor control and easy cleanup, along with a durable sweeper kit comprising a dust pan and brush...
Hands Stay Clean with Mess Cleaner: No more accidental skin contact with pet messes, your hands stay squeaky clean throughout the cleanup process with upto 40 uses, eliminating the yucky factor of...
Essential Oil Aroma: Enjoy a refreshing blend of essential oils that deodorize pet odors as you clean up. It's safe for both dogs and cats with a fresh-smelling environment after every use.
Multipurpose Uses: This isn't just for litter boxes! Use it to deodorize all the hard surfaces where accidents may occur with zero residue or odor left behind. It's also handy for quickly cleaning up...
Safe & Non-Toxic: Formulated with non-toxic ingredients, this is safe for use around your beloved pets at home. You can have peace of mind knowing it won't harm your furry friends.

ON SALE NOW!8

urineOFF Puppy & Dog Pet Stain Remover | Freshly Scented Carpet Cleaner | Bio Enzymatic Stain & Urine Odor Eliminator | Pet Safe Cleaner | 32 oz.

BIO ENZYMATIC — Not just a cover up, our pet enzyme urine cleaner directly targets uric acid & effectively removes all components of urine stain and pet odor.
ELIMINATES ODORS — Pet stain remover leaves surfaces smelling fresh and clean while discouraging territory marking behavior by removing strong odors from pet stains.
MULTI–SURFACE — Urine stain & odor remover and enzyme neutralizer can be used on carpets, rugs, hardwood floors, tile, linoleum and much more.
PLANET & PET FRIENDLY — Proudly made in the USA and formulated without bleach & chlorine. USDA certified biobased enzyme neutralizer that is safe for pets and people.
URINE OFF — From new puppies to everyday messes, Urine OFF's pet friendly cleaning supplies can help keep your home clean and fresh.

Snarky Pets Stain & Odor Remover – Enzyme-Powered Cleaner for Pet Accidents on Carpet, Furniture & Floors – 32 oz Spray – Safe for Dogs, Cats & Homes

DESTROYS STAINS & SMELLS AT THE SOURCE Not just masking odors – our enzyme-powered formula evicts the stink for good.
SAFE FOR PETS & HUMANS (YES, EVEN TODDLERS) No harsh chemicals, no drama. Just clean, fresh, non-toxic peace of mind.
WORKS ON EVERYTHING BUT YOUR EX’S CONSCIENCE Carpets, couches, hardwood, tile, crates, bedding—you name it.
STOP THE REPEAT OFFENDERS Eliminates lingering scent markers so pets don’t keep peeing in the same spot. Genius
SNARKY PETS GUARANTEE: LOVE IT OR BLAME THE DOG We stand by our spray. If it doesn’t work, you don’t pay. No BS.

BARN BE GONE Superhero Strength Stain & Pet Odor Eliminator | Enzyme Carpet Cleaner Spray for Pets | Pet Stain Remover for Dog and Cat Urine Destroyer | Small Pet and Puppy Supplies | Pee Deodorizer

✨REMOVES STAINS AND ODORS: Keep the Barn Smell out of your Home with Barn Be Gone. Eliminates the stain and stink all in one cleaner
✨NATURAL ENZYME BLEND: Destroy the stains and smells completely with our proprietary enzymatic formula that leaves no stain or smell behind
✨MUST HAVE: For puppy, kitten, dog, cat, and small animals. Pee, urine, poop, puke, vomit, feces, and yuck remover for floors, sofa, bedding, curtains, carpets, clothing, litter boxes, kennels,...
✨WHAT YOU GET: Superhero Strength Pet Odor and Stain remover ready to battle the gross on most any surface
✨WE MAKE IT RIGHT: Not only can you rest assured that all of our products are covered by Amazon’s Return Policy, on the Farm, we will always stand by our products

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You may also be interested to read on Dog Urine Neutralizers

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Last update on 2025-11-10 . Images from Amazon Product Advertising API. As an Amazon Associate, I get commissions for purchases made through links in this post.