Top 6 Best Drugs and Supplements to use as an alternative To Apoquel For Dogs
Apoquel is the first Janus Kinase Inhibitor (JAK) approved for veterinary use as allergy medication. Apoquel work by lowering the dog’s immune system, providing rapid and sustained relief of itching, scratching, and skin lesions without causing the side effects associated with glucocorticoid treatments. Although Apoquel is effective when treating dogs allergy, it has a variety of adverse reactions, including vomiting, diarrhea, or the formation of subcutaneous and dermal masses which will cause dog health issues.
In some cases, a dog owner would want to use an alternative for Apoquel when Apoquel stopped working.
For these reasons, you as a dog owner may want to look for Apoquel alternatives for dogs.
Benadryl
Benadryl is the brand name of a medicine called diphenhydramine hydrochloride (there is also Benadryl
that contains acrivastine). Diphenhydramine hydrochloride is an antihistamine and does not require a
prescription. It helps pets relieve itching and scratching, making it a great alternative to Apoquel for
dogs. It is available as tablets, capsules, and liquid gels in various concentrations or milligrams.
It is sometimes combined with other drugs, so you need to read the package leaflet carefully –
diphenhydramine has to be the only drug in the product you buy for your dog. Other drugs are not
tested yet, such as acrivastine, or are toxic to pets, such as pseudoephedrine.
If your pet has mild itching, then Benadryl is one of the best alternatives to Apoquel for dogs.
Benadryl can heal a variety of dog allergies symptoms, ranging from:
- Itching and scratching
- Watery red eyes and nose
- Skin rash
- Hives
- Breathing difficulties and wheezing


Vet’s Best Seasonal Allergy Relief
Vet’s Best Seasonal Allergy Relief Dog Supplement is a supplement that makes a great alternative to Apoquel for dogs.
It is a product made from natural ingredients, with the most active being:
- Quercetin – is a natural flavonoid obtained from plants that is rich in antioxidants. It helps maintain healthy histamine levels, protects against free radical damage, and strengthens the immune system.
- Stinging nettle extract – strengthens the immune system and helps maintain healthy moisture content of both skin and fur.
- Citrus bioflavonoid complex – is a source of antioxidants that provide protection against free radicals, reducing oxidative stress.
- Perilla Leaf Extract – is rich in powerful antioxidants, providing protection and assisting the pet’s organism in combating environmental pollutants.


If you are looking for an all-natural ingredients supplement, Vet’s Best Seasonal Allergy Relief Dog Supplement makes a great alternative to Apoquel for dogs.
PetLab Co. Itch Relief Chews
PetLab Co. Itch Relief Chews contains omega 3 fatty acids, honey, turmeric, and vitamin E. All these ingredients help improve skin conditions and your pet’s coat.
This product can be used for:
- Itching relief
- Dry and flaky skin
- Inflamed skin
It also hydrates the skin and combats skin allergies, which make it a good alternative to Apoquel for dogs.


It your dogs has a mild skin condition that causes itching, PetLab Co. Itch Relief Chews can be a good alternative to Apoquel for dogs.
Yucca Supplement
Yucca Supplement contains Yucca extract that can be used to treat a variety of dermal conditions in pets, including dermatitis, making it a good alternative to Apoquel for dogs.
These supplements are rich in vitamin A, B, and C, potassium, calcium, phosphorus, iron, manganese, and copper.
Yucca extract is used in dogs as:
- Itching reliever – it reduces the itchiness caused by allergies and dermatitis and helps soothe hot spots and skin disorders.
- Natural anti-inflammatory – the steroidal saponins work as natural cortisone. It helps with hip dysplasia, arthritis, bone, and joint problems, stomach irritation, and bowel and bladder problems.
- Joint health – promotes the formation of healthy cartilage and reduces joint inflammation.
- Reduces odor – it acts as a natural odor control by detoxifying the body.
- Digestive aid – it helps soothe the intestines.


CBD Oil
CBD Oils can be given to dogs for a pain-free life. They stimulate lipid-based neurotransmitters and activate various receptors, especially those that balance the body.
CBD oil can help optimize and repair the body at the cellular level, keeping the immune system at physiological parameters.
CBD oil has anti-inflammatory, antibacterial, and antifungal properties.
The anti-inflammatory properties can help your dog to stop scratching because the skin will no longer be inflamed and the itching will be diminished.


CBD oil is considered safe for pets, can reduce itching, and therefore could be considered a good Apoquel alternative for dogs, especially those with mild forms of allergic or atopic dermatitis.
Zyrtec
Zyrtec or others that contain cetirizine are used primarily in dogs to treat the symptoms of allergic and atopic dermatitis.
Cetirizine is a second-generation antihistamine that can be prescribed to dogs suffering from pruritus caused by allergic dermatitis.


You can try cetirizine-based medication if your dog does not respond well to Apoquel treatment or you are afraid that it has too many severe side effects. Cetirizine is a good Apoquel alternative for dogs if used in the short term.
Other Alternatives to Consider:
- Allergy & Itch Relief: Our dog allergy relief bites provide anti-itch solution for dogs, offering natural aid for allergic reactions. The chews help boost immunity, improve health & address seasonal...
- Customer Satisfaction: Enjoy peace of mind with our dog allergy chews. We offer a 90-day guarantee and a hassle-free refund if your pet doesn’t love our soft chews.
- Tasty & Easy: Unlike pills & tablets, our chewable treats offer itch relief for dogs with allergies in a delicious chewing form that every pup enjoys, making them the best choice for allergy remedies.
- Stop the Itch: This dog skin and coat helps stop severe itching and prevent dry skin, rash, hot spot, ears issues, scratching, and paw licking—a natural remedy for dogs' allergies.
- Advanced Formula: Our dog itching skin relief treats include natural antihistamine, fish oil (omega from salmon), turmeric, and quercetin to provide extra strength allergy relief for dogs' itching.
- Treat Your Pup to Pawsome Ingredients - Made with premium ingredients that support digestive function, the immune system, and seasonal allergies, these chews are great for your doggie.
- Pawsome Immune Support - Zesty Paws Allergy & Immune Bites are pet supplements that support immune and digestive function, and may help maintain normal histamine levels for your doggy.
- Featuring EpiCor Pets - EpiCor Pets is a whole food yeast fermentate that helps support the immune system for your canine companion.
- Supports Immunity - Includes Colostrum and Astragalus Root which may support normal histamine levels and immune response.
- Gut Health - These chewables contain probiotics (with Lactobacillus acidophilus probiotic) to support normal gut flora for your pup.
- ALLERGY RELIEF: Made with premium ingredients to support digestion and immune function, this allergy relief for dogs offeres relief from itchy discomfort and promote overall well-being for your furry...
- IMMUNE SYSTEM SUPPORT: These allergy chews for dogs and itchy skin feature EpiCor Pets, a whole food yeast fermentate, to help strengthen your dog's immune system for healthy responses
- ITCHY DOG SKIN RELIEF: Contains Colostrum and Astragalus Root, Zesty Paws Allergy Relief Chews provide relief for itchy skin and support normal histamine levels, keeping your dog's skin comfortable
- DOG GUT HEALTH PROBIOTICS: With dog probiotics like Lactobacillus acidophilus, these chews help maintain normal gut flora, enhancing your dog's digestive health and boosting overall wellness
- OMEGA-3 BENEFITS: Provides your dog supplies with Omega-3 fatty acids EPA and DHA, supporting immune health with dog skin allergy relief benefits while providing itch relief for dogs
- ALLERGY RELIEF: Made with premium ingredients to support digestion and immune function, this allergy relief for dogs offeres relief from itchy discomfort and promote overall well-being for your furry...
- IMMUNE SYSTEM SUPPORT: These allergy chews for dogs and itchy skin feature EpiCor Pets, a whole food yeast fermentate, to help strengthen your dog's immune system for healthy responses
- ITCHY DOG SKIN RELIEF: Contains Colostrum and Astragalus Root, Zesty Paws Allergy Relief Chews provide relief for itchy skin and support normal histamine levels, keeping your dog's skin comfortable
- DOG GUT HEALTH PROBIOTICS: With dog probiotics like Lactobacillus acidophilus, these chews help maintain normal gut flora, enhancing your dog's digestive health and boosting overall wellness
- OMEGA-3 BENEFITS: Provides your dog supplies with Omega-3 fatty acids EPA and DHA, supporting immune health with dog skin allergy relief benefits while providing itch relief for dogs
- Effective Dog Itch Relief: Our best itchy skin relief for dogs chews provide relief from allergies and serve as an excellent alternative to apoquel. Our product is the best solution for dog allergies
- Dry Itchy Skin Relief with Omega-3: Our allergy medicine for dogs uses a blend of natural ingredients to regulate histamine response, providing strong and natural relief from dog itching.
- Support a Healthy Immune System And Gut: Our dog itching skin relief treats boost the immune response and balances gut flora, providing probiotic support that's essential for your dog's well-being.
- Made in The U.S.A, Vet Formulated: Our itchy dog relief bites are formulated by Vets in an FDA-registered facility that meets the highest quality standards.
- Premium Natural Ingredients Give Results: No Added Sugar, Wheat, Corn, Gmo or Preservatives. We are committed to using only best ingredients that deliver results in our dog itchy skin relief chews
- SAME INGREDIENTS: These PETARMOR tablets contain the same active ingredient as BENADRYL Allergy ULTRATABS.
- AFFORDABLE AT-HOME TREATMENT: Skip the trip to the vet with PETARMOR's Antihistamine tablets for dogs. The affordable at-home treatment.
- PROVIDES TEMPORARY RELIEF: This skin health supplement for dogs treats sensitive itchy skin, insect bites, and stings.
- EASY TO USE: These antihistamine tablets are simple and easy to use.
- COST-SAVINGS: 100 PETARMOR tablets in each container, 25 mg each.
- Effective Dog Itch Relief: Our Tasty best itchy skin relief for dogs chews provide relief from allergies and serve as an excellent alternative to apoquel. Vet Treat's pet allergy chews is the best...
- Dry Itchy Skin Relief with Omega-3, Fish oil, Colostrum: Vet Treat allergy medicine for dogs uses a blend of natural ingredients to regulate histamine response, providing strong and natural relief...
- Support a Healthy Immune System And Gut: Our dog itching skin relief treats boost the immune response and balances gut flora, providing probiotic support that's essential for your dog's well-being.
- Vet Formulated - Made in The U.S.A : Vet Treat itchy dog relief bites are formulated by Vets in an FDA-registered facility that meets the highest quality standards plus 3rd party Lab Tested.
- Premium Natural Ingredients Give Results: No Added Sugar, Wheat, Corn, Gmo or Preservatives. We are committed to using only best ingredients that deliver results in our dog itchy skin relief chews
- Vet Formulated, Made in the USA: Harness the immune and allergy support power of Mighty Waggables! Formulated by veterinarians and proudly made in the USA, for allergy support that will make your pups...
- Soothe the Itch: Our immune and allergy supplement unleashes the dynamic power of Omega-3's, Quercetin, and Turmeric to promote immune system health and support your pups season allergy response.
- Mighty Support for Mighty Dogs: Mighty Immune + Itch is expertly formulated to support dog itch and allergy responses, maintain skin moisture and promote immune health. Give your dog the support they...
- Bacon Flavored Boost: We know how important taste is for your furry friend, which is why Mighty Immune + Itch comes in a delicious bacon flavor. Say goodbye to the struggle of giving your dog...
- Owned and Operated in Rochester, NY: Here at Mighty Paw we are dog people, just like you. We know as a pet parent you refuse to settle for nothing but the best for your pup… and neither do we....
- Advanced Allergy & Itch Relief for Dogs: Our Dog Allergy Chews offer comprehensive support against environmental pollutants, food, and seasonal allergies, reducing symptoms like paw licking and...
- Strengthened Immune System: Each allergy relief for dogs itching chew is an immune booster, fortified with a special blend of nutrients and vitamins to enhance your dog's defense against allergens
- Up to 2 Month Supply: With 170 immune treats in one package, your dog will be well supplied with the care they need to manage uncomfortable skin and coat issues. Itch relief for dogs
- Formulated for All Dogs: Created with every dog in mind, our dog itchy skin relief are perfect for all ages and sizes—from playful puppies to wise seniors—so your loyal companion gets the...
- Veterinarian Formulated & USA Made: Trust in the premium quality of our dog skin allergy relief, which are formulated by veterinarians and manufactured in the USA within an FDA-registered facility...
- BEST ITCHY SKIN RELIEF FOR DOGS: Vet’s Best Seasonal Allergy Supplements support dogs with seasonal allergy discomfort by promoting healthy skin moisture and maintaining normal histamine...
- VET-FORMULATED ITCHY SKIN TREATMENT FOR DOGS: Created by veterinarians, this soothing formula combines plant-based ingredients like nettle leaf, perilla seed, and Vitamin E to calm itchy skin and...
- DOG ALLERGY RELIEF CHEWABLE TABLETS: These tasty chewable tablets are easy to give directly or mixed with your dog’s meal. Designed for convenience and palatability, they help support your dog’s...
- PET PARENT APPROVED: Dog allergy relief infused with ocean kelp to support nutrient absorption, healthy digestion, and a strong immune response—helping your furry friend feel comfortable and...
- QUALITY YOU CAN TRUST: Every bottle features the National Animal Supplement Council (NASC) Seal of Approval, reflecting our commitment to product quality, safety, and transparency so you can feel...
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